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Antihistamines. If your itchiness is due to an allergic reaction, over-the-counter antihistamines can help. They work by blocking the action of histamine, a by H Okutani 2024 Cited by 2Antihistamines have limited effects on opioid-induced pruritus, and a possible sedative effect may suppress the itch-scratch cycle (Krajnik ribasphere For most pruritus sufferers, itching becomes noticeably greater just prior to falling asleep, so sedative antihistamines can be particularly effective. There Incidence and prevalence. The incidence of pruritus is 83% in postpartum patients and 69% in non-pregnant patients including males and females.[4,5,6,7] Pregnant women seem to be more susceptible to pruritus after neuraxial opioid administration than other populations, with incidence of %.[2,8,9] In contrast, after orthopedic surgery, the incidence of pruritus after intrathecal opioid
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